Statins for Cholesterol Control

Statins are a class of prescription drugs that are the most widely used and effective medications for lowering LDL ("bad") cholesterol. They work by inhibiting an enzyme in the liver called HMG-CoA reductase, which is a key step in the body's production of cholesterol. By lowering cholesterol production, they reduce the amount of LDL and, more importantly, Apolipoprotein B (ApoB) particles in the bloodstream. ApoB is the particle that carries cholesterol and is considered the primary driver of atherosclerosis (the buildup of plaque in the arteries). By aggressively lowering ApoB, statins are a cornerstone of cardiovascular disease prevention and have been proven in countless studies to reduce the risk of heart attacks and strokes. Since cardiovascular disease is a major component of biological aging, the use of statins in appropriate individuals is a powerful tool for extending healthspan. The main side effect of concern is muscle pain, though its actual incidence is debated.