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NAD+ & Precursors (NMN, NR)

NAD+ & Precursors (NMN, NR)

By Dr. Sofia Reyes
Published on July 8, 2022
Cellular Energy
DNA Repair
Metabolic Health

NAD+ is a critical coenzyme for cellular energy and repair that declines with age. Boosting it via precursors is a key strategy in longevity science.

NAD+ (Nicotinamide Adenine Dinucleotide) is one of the most critical molecules in the body, essential for life. It is a coenzyme found in every cell that plays a central role in two key processes: energy metabolism and DNA repair. NAD+ is required by mitochondria to convert the food we eat into cellular energy (ATP). It is also used as a fuel source by sirtuins and PARPs, which are proteins that regulate cellular health and repair DNA damage. A hallmark of aging is a steep decline in NAD+ levels, which leads to mitochondrial dysfunction and an accumulation of cellular damage. This directly contributes to a higher biological age. Supplementing with NAD+ precursors like NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) is a leading strategy in longevity science to replenish these declining levels, thereby improving cellular energy, enhancing DNA repair, and promoting a more youthful cellular state.

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