Fisetin: The Senolytic Supplement

Fisetin is a natural flavonoid found in many fruits and vegetables, with strawberries having one of the highest concentrations. It has gained significant attention in the longevity community as a potent "senolytic." Senolytics are compounds that can selectively induce the death of senescent cells. Senescent cells are old, dysfunctional "zombie" cells that accumulate with age. They stop dividing but refuse to die, instead secreting a cocktail of inflammatory signals (called the SASP) that damages surrounding healthy tissue and accelerates the aging process. By helping to clear out these senescent cells, fisetin can reduce the body's inflammatory burden and restore a more youthful cellular environment. This direct targeting of a core hallmark of aging makes it one of the most exciting supplemental strategies for lowering biological age.