CJC-1295 & Ipamorelin Peptide Stack

The combination of CJC-1295 and Ipamorelin represents one of the most popular and effective peptide stacks for stimulating the body's natural production of growth hormone (GH). This stack works by targeting the GH axis through two distinct and synergistic mechanisms, creating a powerful yet more natural pulse of growth hormone compared to direct injections of synthetic HGH. CJC-1295 is a Growth Hormone-Releasing Hormone (GHRH) analog. Its primary role is to signal the pituitary gland to release more growth hormone. The version typically used includes a "Drug Affinity Complex" (DAC), which extends its half-life, allowing for a sustained increase in GH levels. Ipamorelin is a Growth Hormone Secretagogue Receptor (GHSR) agonist, also known as a Ghrelin mimetic. It works on a separate receptor in the pituitary to stimulate GH release and has the added benefit of being highly selective, meaning it primarily releases GH without significantly affecting other hormones like cortisol or prolactin. This dual-action approach—stimulating the pituitary from two different angles—results in a strong, rhythmic release of growth hormone that more closely mimics the body's natural patterns.

The link between this peptide stack and biological age is directly tied to the well-documented decline of growth hormone with age, a phenomenon known as somatopause. This age-related decline in GH is associated with a host of changes we typically associate with aging: increased body fat (especially visceral fat), decreased muscle mass (sarcopenia), reduced bone density, poorer sleep quality, and a general decline in vitality and recovery. By restoring GH levels to a more youthful state, the CJC-1295 and Ipamorelin stack aims to counteract these age-related changes. The resulting benefits—improved body composition, enhanced muscle repair and growth, deeper and more restorative sleep, stronger bones, and improved skin quality—are all markers of a lower biological age. Essentially, the stack helps to shift the body's anabolic-to-catabolic ratio back towards a more youthful, regenerative state, helping to preserve and restore physiological function that is typically lost with age.