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Cardarine (GW-501516) Research

Cardarine (GW-501516) Research

By Dr. Liam Griffin
Published on October 8, 2024
Endurance
Fat Loss
Performance
Metabolic Health

Cardarine is a PPARδ receptor agonist researched for its ability to dramatically increase endurance and fat loss by switching the body’s fuel preference to fat.

Cardarine (GW-501516) is a research chemical that is a PPARδ (Peroxisome Proliferator-Activated Receptor delta) agonist. It is not a SARM or a steroid. It works by activating the PPARδ pathway, which plays a key role in energy metabolism. Activation of this pathway dramatically increases the body's ability to use fat as a primary energy source. It also has been shown to have a profound effect on endurance. In studies, mice treated with Cardarine were able to run for significantly longer distances before exhaustion. This combination of enhanced endurance and a metabolic shift towards fat-burning makes it a highly sought-after compound for athletes and those looking to improve body composition. By improving mitochondrial function and metabolic flexibility, Cardarine targets key aspects of a youthful metabolism. However, its development was halted due to concerns about it causing cancer in animal studies at high doses over long periods, and its long-term safety in humans is unknown, making its use highly experimental.

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